ENGINEERING IN LIFE SCIENCES

Engineering in Life Sciences (ELS) focuses on engineering principles and innovations in life sciences and biotechnology. Life sciences and biotechnology covered in ELS encompass the use of biomolecules (e.g. proteins/enzymes) and cells (microbial, plant and mammalian origins) for biosynthesis, biotransformation, cell-based treatment and bio-based solutions in industrial and pharmaceutical biotechnologies as well as in biomedicine. ELS especially aims to promote interdisciplinary collaborations among biologists, biotechnologists and engineers for quantitative understanding and holistic engineering (design-built-test) of biological parts and processes in the different application areas. Applying this engineering mindset, ELS addresses scientific questions and technologies, for example, regarding:? Engineering electron transfer for biosynthesis and biotransformation (e.g. via photo- and electrobiotechnology)? Developing quantitative tools for engineering of biomolecules (e.g. DNA/genome, RNA and proteins) and bioproduction chassis? Accessing novel biomolecules and biomaterials (e.g. proteins, natural and aroma compounds, fine chemicals and building blocks)? Engineering metabolic pathways and their regulation (e.g. in the context of metabolic engineering and synthetic biology)? Unravelling cellular regulation and cell-to-cell interactions (e.g. microbiome, co-cultures, stem cells and tissues)? Engineering novel bioreactors and bioprocesses (e.g. for the production of biopharmaceuticals, fine chemicals, commodities and biofuels, including use of waste streams and alternative feedstock)As such, the journal ELS covers the whole range of modern biochemical engineering and biotechnology comprising biomolecule, bioprocess, metabolic and biosystems engineering. Manuscripts are expected to address the engineering principles and innovations at different molecular and process levels with indicative numbers or performance parameters. Innovative methods and tools for these purposes are also within the scope of ELS.

生命科学工程(ELS)关注生命科学和生物技术的工程原理和创新。ELS涵盖的生命科学和生物技术包括利用生物分子(例如蛋白质/酶)和细胞(微生物、植物和哺乳动物起源)进行生物合成、生物转化、基于细胞的治疗和基于生物的解决方案，用于工业和制药生物技术以及生物医学。ELS特别旨在促进生物学家、生物技术专家和工程师之间的跨学科合作，以便对不同应用领域的生物部件和过程进行定量理解和整体工程(设计-构建测试)。应用这种工程思维，ELS处理科学问题和技术，例如:?生物合成和生物转化的工程电子传递(例如通过光电生物技术)?为生物分子工程(如DNA/基因组、RNA和蛋白质)和生物生产底盘开发定量工具?获取新的生物分子和生物材料(如蛋白质、天然和芳香化合物、精细化学品和构建块)?工程代谢途径及其调控(例如在代谢工程和合成生物学的背景下)?阐明细胞调控和细胞间相互作用(如微生物组、共培养、干细胞和组织)?工程新型生物反应器和生物工艺(例如用于生产生物制药、精细化学品、大宗商品和生物燃料，包括废物流和替代原料的使用)因此，ELS杂志涵盖了现代生物化学工程和生物技术的所有领域，包括生物分子、生物过程、代谢和生物系统工程。预计手稿将涉及不同分子和工艺水平的工程原理和创新与指示数字或性能参数。用于这些目的的创新方法和工具也属于ELS的范围。