EUROPEAN CELLS & MATERIALS

ECM provides an interdisciplinary forum for publication of preclinical research in the musculoskeletal field (Orthopaedics, Trauma, Maxillofacial (including dental) and Spine). ECM Journal is published by the AO Research Institute Davos, a Not-for-Profit foundation in Switzerland.? Assessment of materials for biomedical useManuscripts must have an important biological dimension, reporting effects at the cellular, tissue or organismic levels. Mechanotransduction papers with musculoskeletal cells are within ECM scope. In vitro cytocompatibilty studies should use primary cells or more than one cell line and provide more than just simple descriptions of cell viability, spreading, proliferation, mineralisation etc. Major improvements with in vitro, ex vivo or in vivo models and relevant opinion papers may be considered. Papers focussing purely on material properties or biomechanics properties (alone or combined, without a strong biological dimension) will not be entertained. Manuscripts on effects of surfaces, coatings, additives etc. in preventing bacterial adhesion must also consider the effect on eukaryotic cells (to be mentioned within the abstract) or refer to previously published data using the exact same surfaces. High level submissions on infection prevention, diagnostics, therapy and major improvement with in vitro or in vivo models within the musculoskeletal field (as defined by ECM below) are within ECM scope.? Tissue Engineering and Regenerative Medicine (TERM)Manuscripts concerning aspects of the repair or regeneration of connective and mineralized tissues within the musculoskeletal field (as defined by ECM below) will be considered. TERM papers where only biomechanical testing is utilized will not be considered, but biomechanics may be within a TERM submission.? Structure, function, biology and biomechanics of connective and mineralized tissuesManuscripts concerning the structure of bone, teeth, cartilage, intervertebral discs, skeletal muscle, tendons and ligaments within the musculoskeletal field (as defined by ECM below) will be considered.? Stem and Progenitor CellsManuscripts concerning stem cell characterization and mechanisms of differentiation as they relate to the connective and mineralized tissues of the musculoskeletal field (as defined by ECM below) will be considered. Note: The use of pooled donor cells should be avoided. When unavoidable, their use needs to be justified convincingly within the manuscript (and within the cover letter). Note: Technical notes and papers focussing purely on computational, material or biomechanical models will not be entertained. Papers must report effects at the cellular, tissue or organismic levels, which is a pre-requisite for possible acceptance of papers for publication in ECM.The clinical relevance of the work must be briefly mentioned within the abstract and in more detail in the paper. Poor abstracts, which do not concisely cover the paper contents will not be sent for review. Incremental steps in research will not be entertained by ECM journal. Cross-disciplinary papers that go across our scope areas are within ECM scope.ECM 's definition of the musculoskeletal field includes bone, teeth, cartilage, intervertebral discs, skeletal muscle (not smooth or cardiac muscle), tendons and ligaments (it does not include the spinal cord or neural tissues).

ECM为肌肉骨骼领域（骨科、创伤、颌面（包括牙科）和脊柱）的临床前研究提供了一个跨学科论坛。ECM期刊是由AO研究所DavOS，瑞士的非营利基金会出版的。生物医学用材料评估手稿必须有一个重要的生物学维度，在细胞、组织或组织层面上报告效果。肌肉骨骼细胞的机械转导纸在ECM范围内。体外细胞相容性研究应使用原代细胞或多个细胞系，并提供细胞活力、扩散、增殖、矿化等的简单描述。可考虑对体外、体外或体内模型和相关意见文件进行重大改进。仅关注材料特性或生物力学特性（单独或组合，没有强大的生物学维度）的论文将不受欢迎。在防止细菌粘附方面，有关表面、涂层、添加剂等影响的手稿还必须考虑对真核细胞的影响（在摘要中提及），或参考使用完全相同表面的先前发布的数据。有关肌肉骨骼领域（定义见下文）内的体外或体内模型的感染预防、诊断、治疗和重大改进的高水平提交资料在ECM范围内。?组织工程和再生医学（学期）将考虑有关肌肉骨骼领域内结缔组织和矿化组织修复或再生方面的手稿（见下文ECM的定义）。只使用生物力学测试的学期论文将不予考虑，但生物力学可以在学期内提交。?结缔组织和矿化组织的结构、功能、生物学和生物力学将考虑有关骨骼、牙齿、软骨、椎间盘、骨骼肌、肌腱和肌肉骨骼场（定义见下文ECM）内韧带结构的手稿。?干细胞和祖细胞将考虑有关干细胞特征和分化机制的手稿，因为它们与肌肉骨骼场的结缔组织和矿化组织有关（如下面的ECM所定义）。注意：应避免使用集合供者细胞。在不可避免的情况下，它们的使用需要在手稿（以及附信）中得到令人信服的证明。注：仅关注计算模型、材料模型或生物力学模型的技术说明和论文将不予受理。论文必须报告细胞、组织或组织水平的影响，这是可能接受在ECM中发表论文的先决条件。必须在摘要中简要提及这项工作的临床相关性，并在本文中进行更详细的介绍。摘要不好，不能简明扼要地覆盖论文内容，将不送审。《电子商务杂志》不接受研究中的增量步骤。跨范围的跨学科论文在ECM范围内。ECM对肌肉骨骼场的定义包括骨骼、牙齿、软骨、椎间盘、骨骼肌（非平滑肌或心肌）、肌腱和韧带（不包括脊髓或神经组织）。