Aging & Disease (A&D) is a peer reviewed, open access online journal that aspires to publish novel and high-impact findings on central issues pertaining to the biology of aging, pathophysiology of age-related diseases, and innovative therapies for diseases afflicting the elderly population. The diseases of interest include (but not limited to) Stroke, Alzheimer''''s disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes and Hypertension. Studies on animal models as well as human tissues or cells are welcome.Manuscripts in the following areas are of particular interest:(A) Biology of Aging: Mechanisms underlying changes in gene & protein expression Genes, mutations, signaling pathways affecting longevity and successful aging Mechanisms underlying stem cell proliferation, differentiation and senescence Role of stress at organismal and cellular levels Comparative mechanistic studies across species Efficacy of cognitive and physical exercises on longevity and aging Effects of dietary-supplements on longevity and aging (B) Pathophysiology of Age-related Diseases: Disease pathology using cellular and molecular approaches Extrinsic and intrinsic factors influencing disease onset, pathology & progression Effects of physical exercise and environmental enrichment on disease progression (C) Novel treatments for Diseases afflicting the elderly Cellular therapies using specific stem, progenitor or precursor cells Gene therapies using cell grafts or specific vectors Effects of drugs, vitamins, hormones and antioxidants for treatment of diseases
《老化与疾病》(A&D)是一份经同行评审的开放获取的在线期刊，致力于发表有关衰老生物学、与年龄相关疾病的病理生理学和折磨老年人的疾病的创新疗法等核心问题的新颖和高影响力的研究成果。感兴趣的疾病包括(但不限于)中风、阿尔茨海默病、帕金森病、癫痫、痴呆、抑郁症、心血管疾病、癌症、关节炎、白内障、骨质疏松症、糖尿病和高血压。欢迎对动物模型以及人体组织或细胞进行研究。下列领域的手稿特别值得注意:(A)老化生物学:基因和蛋白质表达的潜在变化机制基因、突变、影响寿命和成功衰老的信号通路干细胞增殖、分化和衰老的机制压力在机体和细胞水平上的作用跨物种的比较力学研究认知和体育锻炼对长寿和衰老的作用饮食补充剂对寿命和衰老的影响(B)与年龄有关的疾病的病理生理学:使用细胞和分子方法的疾病病理学影响疾病发生、病理和进展的外在和内在因素体育锻炼和环境丰富对疾病进展的影响(C)治疗老年人疾病的新方法使用特定的干细胞、祖细胞或前体细胞的细胞疗法使用细胞移植或特定载体的基因治疗药物、维生素、激素和抗氧化剂治疗疾病的效果
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